Dating shushu ua


02-Sep-2020 22:57

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Although the blood vessels to dilate and increase the pain and migraine-related symptoms, but this type of neurovascular events currently considered to be the result of the disease rather than the cause.

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[0007] CGRP and base may be correlated to develop and test a large number of migraine of the following compounds, the compound to inhibit release of CGRP (e.g.

In some embodiments, affinity is any of the following: about 200 n M, about IOOn MJ ^] 50n M, approximately IOn Mj ^] In Mj ^ J 500p M, about ΙΟΟρΜ, about 60 p M, about 50 p M, about 20 p M, about 15p M, about 10 p M, about 5p M or about 2p M.

Means any administration of anti-CGRP antagonist antibody may be known in the art: oral, intravenous, subcutaneous, intraarterial, intramuscular, cardiac, spinal, intrathecal, intraperitoneal, intraventricular, sublingual, skin and / or via inhalation.

[0016] In one aspect, the present invention provides a method for treating or preventing at least one vasomotor symptom in an individual, said method comprising administering an effective amount of an anti-CGRP antagonist antibody.

[0017] In one aspect, the present invention provides a method for treating or preventing headache (e.g., migraine and cluster headache) in an individual, said method comprising administering an effective amount of an anti-CGRP antagonist antibody.

The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster headache, and tension headache) and hot flushes, by administering an anti-CGRP antagonist antibody. 13 = 453-464 (2001)) "So far, for the flushing of the most effective therapy is based on hormone therapy, said hormones include estrogens and / or some progestins.



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